Cytological and Histopathology Features of Meibomian Adenocarcinoma in a Dog Terrier Breed

In March 2012, an 8-year-old neutered terrier which was admitted to the Veterinary Surgery Clinics of Faculty of Veterinary Medicine, University of Tehran, Iran. The signalment (i.e. description of appearance of the animals such as sex, breed, age, etc) and anatomical repartition were summarized and focused on pathomorphological explanation. Macroscopically, the mass was gray-reddish and arising from the right lower eyelid with local spread to the upper eyelid and covering the entire globe was observed. Following sedation and local anesthesia, the tumor and globe were expulsed with Cryosurgery. Cytological smears indicated large number of malignant meibomian cells occurring either individually or in clusters also cytology indicated high cellularity and contained small clusters of polygonal to elongated tumor cells. Microscopically, the mass was composed of lobules of various sizes separated with a septum of connective tissue which included with poorly differentiated (grade III), nuclear pleomorphism and polygonal sebaceous cells, also with acinular and sheet-like architecture, the findings are consistent with minimal mitotic activity, extensive invasion, low grade and the presence of hyaline cartilage. Finally, histopathological examination revealed an MAC. *Corresponding author: Dr. Javad Javanbakht, Department of Pathology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran, Tel: +989372512581; E-mail: [email protected] Received May 14, 2012; Accepted July 15, 2012; Published July 19, 2012 Citation: Tavasoli A, Javanbakht J, Shafiee R, Moghaddam ZK, Hassan MA (2012) Cytological And Histopathology Features of Meibomian Adenocarcinoma in A Dog Terrier Breed. J Clin Exp Pathol 2:120. doi:10.4172/2161-0681.1000120 Copyright: © 2012 Tavasoli A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.